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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-A2M / Alpha-2-Macroglobulin Antibody   

Anti-A2M / Alpha-2-Macroglobulin Antibody

Goat Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01023
Predicted Human
Host Goat
Clonality Polyclonal
Isotype IgG
Calculated MW 163291 Da
Dilution ELISA, IE, IHC-P (2.5 µg/ml)
Additional Information
Gene ID 2
Alias Symbol A2M
Other Names A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7
Target/Specificity Recognizes alpha2-Microglobulin. Monospecific when analyzed by immunoelectrophoresis. Only one arc was seen with normal human plasma, of identical mobility to that obtained with purified alpha2-microglobulin.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-A2M / Alpha-2-Macroglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name A2M
Synonyms CPAMD5
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Cellular Location Secreted.
Tissue Location Secreted in plasma.
Research Areas
Citations (0)

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$ 450.00
Cat# ALS18006
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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