|Application ||IHC-P, E, IE|
|Calculated MW||163291 Da|
|Dilution||ELISA, IE, IHC-P (2.5 µg/ml)|
|Other Names||A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7|
|Target/Specificity||Recognizes alpha2-Microglobulin. Monospecific when analyzed by immunoelectrophoresis. Only one arc was seen with normal human plasma, of identical mobility to that obtained with purified alpha2-microglobulin.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-A2M / Alpha-2-Macroglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.|
|Tissue Location||Secreted in plasma.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.