|Application ||IHC-P, E, IE|
|Calculated MW||163291 Da|
|Dilution||ELISA, IE, IHC-P (2.5 µg/ml)|
|Other Names||A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7|
|Target/Specificity||Recognizes alpha2-Microglobulin. Monospecific when analyzed by immunoelectrophoresis. Only one arc was seen with normal human plasma, of identical mobility to that obtained with purified alpha2-microglobulin.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-A2M / Alpha-2-Macroglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.|
|Tissue Location||Secreted in plasma.|
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