Anti-NFKBIA / IKB Alpha / IKBA Antibody (aa15-64)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P25963 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 35609 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 4792 |
---|---|
Alias Symbol | NFKBIA |
Other Names | NFKBIA, IkB-alpha, IKBA, IkappaBalpha, MAD3, NF-kappa-B inhibitor alpha, NFKBI, I-kappa-B-alpha, IKB Alpha, MAD-3 |
Target/Specificity | IkappaB-alpha (Ab-32/36) Antibody detects endogenous levels of total IkappaB-alpha protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-NFKBIA / IKB Alpha / IKBA Antibody (aa15-64) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NFKBIA |
---|---|
Synonyms | IKBA, MAD3, NFKBI |
Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:7479976, PubMed:36651806). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7796813, PubMed:7628694, PubMed:7878466, PubMed:7479976). |
Cellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
- Primary Antibodies
- Cancer
- Cell Biology
- Immunology
- Neuroscience
- Signal Transduction
- Antibody Collections
- GPCR Antibodies
- Viral process
- Host-virus interaction
- RIG-l-like Receptor
- Toll receptor signaling
- Toll-Like Receptor
- Toll-Like receptor signaling
- B cell receptor signaling
- T cell activation
- T cell receptor signaling
- Chemokine signaling
- Inflammation mediated by chemokine and cytokine signaling
- Apoptosis
- Apoptosis signaling
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