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Anti-NFKBIA / IKB Alpha / IKBA Antibody (aa15-64)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P25963
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 35609 Da
Dilution ELISA, IHC-P (1:50), WB
Additional Information
Gene ID 4792
Alias Symbol NFKBIA
Other Names NFKBIA, IkB-alpha, IKBA, IkappaBalpha, MAD3, NF-kappa-B inhibitor alpha, NFKBI, I-kappa-B-alpha, IKB Alpha, MAD-3
Target/Specificity IkappaB-alpha (Ab-32/36) Antibody detects endogenous levels of total IkappaB-alpha protein.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-NFKBIA / IKB Alpha / IKBA Antibody (aa15-64) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFKBIA
Synonyms IKBA, MAD3, NFKBI
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:7479976, PubMed:36651806). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7796813, PubMed:7628694, PubMed:7878466, PubMed:7479976).
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Research Areas
Citations (0)
citation

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Discontinued
Cat# ALS18020
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