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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Anti-UBR5 Antibody (aa14-63)   

Anti-UBR5 Antibody (aa14-63)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95071
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 309352 Da
Dilution ELISA, IHC-P (1:50), WB
Additional Information
Gene ID 51366
Alias Symbol UBR5
Other Names UBR5, DD5, EDD, HHYD, KIAA0896, Progestin-induced protein, Ubiquitin-protein ligase, EDD1, HYD, Progestin induced protein
Target/Specificity EDD antibody detects endogenous levels of EDD.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-UBR5 Antibody (aa14-63) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBR5
Synonyms EDD, EDD1, HYD, KIAA0896
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Cellular Location Nucleus.
Tissue Location Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney
Research Areas
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$ 450.00
Cat# ALS18043
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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