|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||33670 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||HNRNPC, HNRPC, HnRNP C1/C2, HNRNP|
|Target/Specificity||HnRNP C1/C2 antibody detects endogenous levels of hnRNP C1/C2.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-HNRNPC / HNRNP C Antibody (aa222-271) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non- coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre- mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'- UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).|
|Cellular Location||Nucleus. Note=Component of ribonucleosomes.|
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