|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||23858 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||RGS1, 1R20, B-cell activation protein BL34, BL34, Early response protein 1R20, IER1, IR20|
|Target/Specificity||RGS1 Antibodyantibody detects endogenous levels of RGS1.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-RGS1 Antibody (aa102-151) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||1R20, BL34, IER1|
|Function||Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol|
|Tissue Location||Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738)|
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