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Anti-TSC22D1 / TSC22 Antibody (aa24-73)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q15714
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 109677 Da
Dilution ELISA, IHC-P (1:50), WB
Additional Information
Gene ID 8848
Alias Symbol TSC22D1
Other Names TSC22D1, Cerebral protein 2, Ptg-2, Regulatory protein TSC-22, TSC22 domain family protein 1, TGFB1I4, TSC22, TSC22 domain family, member 1, KIAA1994, TGFbeta-stimulated clone 22
Target/Specificity TSC22D1 antibody detects endogenous levels of TSC22D1.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-TSC22D1 / TSC22 Antibody (aa24-73) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSC22D1 (HGNC:16826)
Function Transcriptional repressor (PubMed:10488076). Acts on the C- type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta- induced transcription of COL1A2; via its interaction with TFE3 at E- boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201).
Cellular Location Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane; Peripheral membrane protein [Isoform 2]: Cytoplasm. Nucleus Mitochondrion
Tissue Location Ubiquitously expressed in adult tissues (PubMed:8651929, PubMed:26752201). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551).
Research Areas
Citations (0)
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Discontinued
Cat# ALS18060
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