Anti-TSC22D1 / TSC22 Antibody (aa24-73)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q15714 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 109677 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 8848 |
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Alias Symbol | TSC22D1 |
Other Names | TSC22D1, Cerebral protein 2, Ptg-2, Regulatory protein TSC-22, TSC22 domain family protein 1, TGFB1I4, TSC22, TSC22 domain family, member 1, KIAA1994, TGFbeta-stimulated clone 22 |
Target/Specificity | TSC22D1 antibody detects endogenous levels of TSC22D1. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-TSC22D1 / TSC22 Antibody (aa24-73) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TSC22D1 (HGNC:16826) |
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Function | Transcriptional repressor (PubMed:10488076). Acts on the C- type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta- induced transcription of COL1A2; via its interaction with TFE3 at E- boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). |
Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane; Peripheral membrane protein [Isoform 2]: Cytoplasm. Nucleus Mitochondrion |
Tissue Location | Ubiquitously expressed in adult tissues (PubMed:8651929, PubMed:26752201). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551). |
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