|Application ||IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||40524 Da|
|Dilution||ELISA, IHC-P (1:50)|
|Other Names||CCR5, C-C chemokine receptor 5, CD195 antigen, CD195, C-C CKR-5, Chemokine c-c motif receptor 5, Chemr13, CMKBR5, CKR5, Cc chemokine receptor 5, CCCKR5, CCR-5, Ccr5 receptor, Chemokine receptor CCR5, HIV-1 fusion coreceptor, IDDM22, C-C chemokine rec ...|
|Target/Specificity||CCR5 Antibody detects endogenous levels of total CCR5 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CCR5 Antibody (aa292-341) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung|
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