|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||12580 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4E-binding protein 1|
|Target/Specificity||4E-BP1 Antibody detects endogenous levels of total 4E-BP1 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-EIF4EBP1 / 4EBP1 Antibody (aa35-84) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.|
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