|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||15383 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||MRPL41, BMRP, L41mt, MRP-L41, PIG3, MRP-L27, MRP-L27 homolog, Proliferation-inducing gene 3, RPML27|
|Target/Specificity||MRPL41 Antibody detects endogenous levels of total MRPL41 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MRPL41 / PIG3 / BMRP Antibody (aa81-130) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BMRP, MRPL27, RPML27|
|Function||Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).|
|Tissue Location||Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level)|
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