|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||29203 Da|
|Dilution||ELISA, IHC-P (1:100), WB|
|Other Names||CTDSP1, NIF3, NLIIF, NLI-IF, SCP1, NLI-interacting factor 3, Small CTD phosphatase 1|
|Target/Specificity||CTDSP1 Antibody detects endogenous levels of total CTDSP1 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CTDSP1 / SCP1 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NIF3, NLIIF, SCP1|
|Function||Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.|
|Cellular Location||Nucleus. Note=Colocalizes with RNA polymerase II|
|Tissue Location||Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.|
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