|Application ||WB, IHC-P, IF, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||85467 Da|
|Dilution||ELISA, IF, IHC-P (1:50), WB|
|Other Names||CHPF, CSS2, Chondroitin sulfate synthase 2, CHSY2|
|Target/Specificity||CHSY2 Antibody detects endogenous levels of total CHSY2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CHPF / CHSY2 Antibody (aa631-680) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress.|
|Cellular Location||Isoform 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cytoplasm, cytosol Isoform 2: Mitochondrion matrix|
|Tissue Location||Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.|
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