|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||23949 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||KCNMB4, BK beta 4, BK channel subunit beta-4, BKbeta4, Hbeta4, K(VCA)beta-4, Slowpoke beta 4, Maxi K channel subunit beta-4, Maxi K beta 4, Slo-beta-4|
|Target/Specificity||MaxiK beta antibody detects endogenous levels of MaxiK beta.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-KCNMB4 Antibody (aa70-119) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.|
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