|Application ||WB, IHC-P, E|
|Calculated MW||53497 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||SMAD6, AOVD2, HSMAD6, HsT17432, SMAD 6, MADH7, Mothers against DPP homolog 6, SMAD family member 6, MAD homolog 6, MADH6|
|Target/Specificity||Smad6 antibody detects endogenous levels of Smad6.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SMAD6 Antibody (aa323-372) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.|
|Tissue Location||Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.