|Application ||WB, IHC-P, E|
|Calculated MW||53497 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||SMAD6, AOVD2, HSMAD6, HsT17432, SMAD 6, MADH7, Mothers against DPP homolog 6, SMAD family member 6, MAD homolog 6, MADH6|
|Target/Specificity||Smad6 antibody detects endogenous levels of Smad6.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SMAD6 Antibody (aa323-372) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.|
|Tissue Location||Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue|
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