|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||64746 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||CAMKK2, CaM-kinase kinase 2, CaMKK beta, CAMKKB, CaM-KK beta, CaMKK, CAMKK beta protein, CaMKK 2, CaMKKbeta, KIAA0787, CaM KKB, CaM-kinase kinase beta, CaM-KK 2|
|Target/Specificity||CAMKK2 antibody detects endogenous levels of CAMKK2.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CAMKK2 Antibody (aa374-423) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.|
|Cellular Location||Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.|
|Tissue Location||Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung|
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