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Anti-CHD1 Antibody (clone 1G2)

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O14646
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b,k
Clone Names 1G2
Calculated MW 196688 Da
Dilution ELISA, IF (10 µg/ml), IHC-P (1:50), WB
Additional Information
Gene ID 1105
Alias Symbol CHD1
Other Names CHD1, ATP-dependent helicase CHD1, CHD-1
Target/Specificity Human CHD1
Reconstitution & Storage Protein A purified
PrecautionsAnti-CHD1 Antibody (clone 1G2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHD1 (HGNC:1915)
Function ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre- mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P40201}. Cytoplasm {ECO:0000250|UniProtKB:P40201}. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250|UniProtKB:P40201}
Tissue Location Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia.
Research Areas
Citations (0)
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Discontinued
Cat# ALS18114
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