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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Anti-CD46 Antibody (clone 169-1-EA.3, Azide-free)   

Anti-CD46 Antibody (clone 169-1-EA.3, Azide-free)

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession P15529
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 169-1-EA.3
Calculated MW 43747 Da
Dilution Flo, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 4179
Alias Symbol CD46
Other Names CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein
Target/Specificity SCR1 epitope of CD46.
Reconstitution & Storage Protein A purified
PrecautionsAnti-CD46 Antibody (clone 169-1-EA.3, Azide-free) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD46
Synonyms MCP, MIC10
Function Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Cellular Location Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single- pass type I membrane protein Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide
Tissue Location Expressed by all cells except erythrocytes.
Research Areas
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$ 395.00
Cat# ALS18121
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