Anti-CDw218a / IL18R1 Antibody (aa32-329)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q13478 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 62304 Da |
Dilution | ELISA (1:20000 - 1:80000), IHC-P (5 µg/ml), WB (1:500 - 1:1000) |
Gene ID | 8809 |
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Alias Symbol | IL18R1 |
Other Names | IL18R1, CD218a antigen, CDw218a, CD218a, IL-1Rrp, IL1 receptor-related protein, IL18RA, Interleukin-18 receptor 1, IL1RRP, IL-18R-1, Cytokine receptor, IL-18R1, IL1R-rp, Interleukin 18 receptor 1 |
Target/Specificity | Human CDw218a / IL18R1. |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-CDw218a / IL18R1 Antibody (aa32-329) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IL18R1 (HGNC:5988) |
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Synonyms | IL1RRP |
Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714). Involved in IL18-mediated IFNG synthesis from T- helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). |
Cellular Location | Membrane; Single- pass type I membrane protein |
Tissue Location | Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850). |
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