|Application ||WB, IHC-P|
|Calculated MW||92463 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:2000)|
|Other Names||ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15|
|Target/Specificity||Human ACE2 / ACE-2|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-ACE2 / ACE-2 Antibody (aa18-237, clone 1G4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.|
|Cellular Location||Processed angiotensin-converting enzyme 2: Secreted|
|Tissue Location||Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level) Expressed in heart, kidney, testis, and gastrointestinal system|
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