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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-IDN3 / NIPBL Antibody (clone KT55)
Anti-IDN3 / NIPBL Antibody (clone KT55)
Rat Anti Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | Q6KC79 |
| Predicted | Human, Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | KT55 |
| Calculated MW | 316051 Da |
| Dilution | ICC (10 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml) |
| Gene ID | 25836 |
|---|---|
| Alias Symbol | NIPBL |
| Other Names | NIPBL, CDLS1, CDLS, Delangin, IDN3, Nipped-B homolog (Drosophila), IDN3-B, Scc2, SCC2 homolog, Nipped-B-like protein |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-IDN3 / NIPBL Antibody (clone KT55) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NIPBL |
|---|---|
| Synonyms | IDN3, SCC2 {ECO:0000303|PubMed:22628566} |
| Function | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double- strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168- dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q6KCD5} |
| Tissue Location | Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung. |
Research Areas
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