|Application ||WB, IHC-P, E|
|Calculated MW||24969 Da|
|Dilution||ELISA, IHC-P (1:100), WB|
|Other Names||SCN4B, LQT10, Navbeta4, Sodium channel subunit beta-4|
|Target/Specificity||SCN4B Antibody detects endogenous levels of total SCN4B protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SCN4B Antibody (aa61-110) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.|
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