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Anti-NAMPT / Visfatin Antibody (clone OMNI379)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E, IP, Flo
Primary Accession P43490
Predicted Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names OMNI379
Calculated MW 55521 Da
Dilution ELISA (1:2000 - 1:10000), Flo (1:1000), ICC (1:500 - 1:1000), IHC-P (1:500 - 1:1000, 15 µg/ml), IP (1:500 - 1:1000), WB (1:2000 - 1:5000)
Additional Information
Gene ID 10135
Alias Symbol NAMPT
Other Names NAMPT, PBEF, Pre-B cell-enhancing factor, VISFATIN, VF, NAmPRTase, PBEF1
Target/Specificity Recognizes human, mouse and rat Nampt.
Reconstitution & Storage Protein G purified
PrecautionsAnti-NAMPT / Visfatin Antibody (clone OMNI379) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PBEF, PBEF1
Function Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Cellular Location Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum
Tissue Location Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues
Research Areas
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$ 395.00
Cat# ALS18154
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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