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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-NAMPT / Visfatin Antibody (clone OMNI379)
Anti-NAMPT / Visfatin Antibody (clone OMNI379)
Mouse Anti Human Monoclonal Antibody
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Application 
| WB, IHC-P, ICC, E, IP, Flo |
|---|---|
| Primary Accession | P43490 |
| Predicted | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | OMNI379 |
| Calculated MW | 55521 Da |
| Dilution | ELISA (1:2000 - 1:10000), Flo (1:1000), ICC (1:500 - 1:1000), IHC-P (1:500 - 1:1000, 15 µg/ml), IP (1:500 - 1:1000), WB (1:2000 - 1:5000) |
| Gene ID | 10135 |
|---|---|
| Alias Symbol | NAMPT |
| Other Names | NAMPT, PBEF, Pre-B cell-enhancing factor, VISFATIN, VF, NAmPRTase, PBEF1 |
| Target/Specificity | Recognizes human, mouse and rat Nampt. |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-NAMPT / Visfatin Antibody (clone OMNI379) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAMPT |
|---|---|
| Synonyms | PBEF, PBEF1 |
| Function | Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1- mediated suppression (By similarity). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100- fold higher concentrations compared to maternal serum |
| Tissue Location | Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues |
Research Areas
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