|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||83598 Da|
|Dilution||IHC-P (1:200), WB (1:500 - 1:2000)|
|Other Names||PIK3R1, p85, p85 Alpha, p85-ALPHA, PI3K regulatory subunit alpha, PI3-kinase subunit p85-alpha, GRB1|
|Target/Specificity||Human PIK3R1 / p85 Alpha|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-PIK3R1 / p85 Alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).|
|Tissue Location||Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)|
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