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Anti-PIK3R1 / p85 Alpha Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P27986
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 83598 Da
Dilution IHC-P (1:200), WB (1:500 - 1:2000)
Additional Information
Gene ID 5295
Alias Symbol PIK3R1
Other Names PIK3R1, p85, p85 Alpha, p85-ALPHA, PI3K regulatory subunit alpha, PI3-kinase subunit p85-alpha, GRB1
Target/Specificity Human PIK3R1 / p85 Alpha
Reconstitution & Storage Affinity purified
PrecautionsAnti-PIK3R1 / p85 Alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIK3R1
Synonyms GRB1
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Tissue Location Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)
Research Areas
Citations (0)

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$ 395.00
Cat# ALS18159
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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