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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-SYT1 / Synaptotagmin Antibody
Anti-SYT1 / Synaptotagmin Antibody
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P21579 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 47573 Da |
| Dilution | IF (1:50 - 1:200), IHC-P (1:200), WB (1:500 - 1:2000) |
| Gene ID | 6857 |
|---|---|
| Alias Symbol | SYT1 |
| Other Names | SYT1, SYT, SVP65, Synaptotagmin, Synaptotagmin 1, SytI, Synaptotagmin I, Synaptotagmin-1 |
| Target/Specificity | Human SYT1 / Synaptotagmin |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-SYT1 / Synaptotagmin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYT1 (HGNC:11509) |
|---|---|
| Synonyms | SVP65, SYT |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707} |
| Tissue Location | Expressed in melanocytes (PubMed:23999003). |
Research Areas
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