|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||29246 Da|
|Dilution||IHC-P (1:200), WB (1:500 - 1:2000)|
|Other Names||CA2, CA-II, CAII, CAC, Car2, Carbonate dehydratase II, Carbonic anhydrase C, Carbonic anhydrase II, Carbonic dehydratase, Carbonic anhydrase 2, Carbonic anhydrase B|
|Target/Specificity||Human CA2 / Carbonic Anhydrase II|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CA2 / Carbonic Anhydrase II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells|
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