|Application ||IHC-P, IF, E|
|Calculated MW||115594 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-P (1.5 - 5 µg/ml)|
|Other Names||NFATC3, NF-AT4, NFATX, NF-AT4c, NFAT4, NF-ATc3|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-NFAT4 / NFATC3 Antibody (clone 3A12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription|
|Tissue Location||Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.