Anti-NFAT4 / NFATC3 Antibody (clone 3A12)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IF, E |
---|---|
Primary Accession | Q12968 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2b,k |
Clone Names | 3A12 |
Calculated MW | 115594 Da |
Dilution | ELISA, IF (10 µg/ml), IHC-P (1.5 - 5 µg/ml) |
Gene ID | 4775 |
---|---|
Alias Symbol | NFATC3 |
Other Names | NFATC3, NF-AT4, NFATX, NF-AT4c, NFAT4, NF-ATc3 |
Target/Specificity | Human Nf-at4c |
Reconstitution & Storage | Protein A purified |
Precautions | Anti-NFAT4 / NFATC3 Antibody (clone 3A12) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NFATC3 |
---|---|
Synonyms | NFAT4 {ECO:0000303|PubMed:7749981} |
Function | Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription |
Tissue Location | Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney Isoform 4 is expressed in thymus and skeletal muscle |
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