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Anti-NFAT4 / NFATC3 Antibody (clone 3A12)

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession Q12968
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b,k
Clone Names 3A12
Calculated MW 115594 Da
Dilution ELISA, IF (10 µg/ml), IHC-P (1.5 - 5 µg/ml)
Additional Information
Gene ID 4775
Alias Symbol NFATC3
Other Names NFATC3, NF-AT4, NFATX, NF-AT4c, NFAT4, NF-ATc3
Target/Specificity Human Nf-at4c
Reconstitution & Storage Protein A purified
PrecautionsAnti-NFAT4 / NFATC3 Antibody (clone 3A12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFATC3
Synonyms NFAT4 {ECO:0000303|PubMed:7749981}
Function Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription
Tissue Location Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney Isoform 4 is expressed in thymus and skeletal muscle
Research Areas
Citations (0)
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$ 533.50
Cat# ALS18179
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