|Application ||IHC-P, IF, E|
|Calculated MW||115594 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-P (1.5 - 5 µg/ml)|
|Other Names||NFATC3, NF-AT4, NFATX, NF-AT4c, NFAT4, NF-ATc3|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-NFAT4 / NFATC3 Antibody (clone 3A12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription|
|Tissue Location||Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle|
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