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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-NPPB / BNP Antibody (clone 2D11)
Anti-NPPB / BNP Antibody (clone 2D11)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | P16860 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3,k |
| Clone Names | 2D11 |
| Calculated MW | 14726 Da |
| Dilution | ELISA, IHC-P (10 µg/ml), IP, WB |
| Gene ID | 4879 |
|---|---|
| Alias Symbol | NPPB |
| Other Names | NPPB, BNP, Natriuretic peptides B, Natriuretic peptide B, Natriuretic protein, Brain type natriuretic peptide |
| Target/Specificity | Human NPPB / BNP |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-NPPB / BNP Antibody (clone 2D11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPPB |
|---|---|
| Function | [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504). Involved in regulating the extracellular fluid volume and maintaining the fluid- electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098). Binds the clearance receptor NPR3 (PubMed:16870210). |
| Cellular Location | [NT-proBNP]: Secreted Note=Detected in blood. [Brain natriuretic peptide 32]: Secreted. Note=Detected in blood. |
| Tissue Location | [Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2138890, PubMed:2136732) Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555). |
Research Areas
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