|Application ||WB, IHC-P, E|
|Calculated MW||58113 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||PSAP, Cerebroside sulfate activator, GLBA, Proactivator polypeptide, Prosaposin, SAP1|
|Target/Specificity||Human PSAP / Prosaposin|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-PSAP / Prosaposin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 184.108.40.206) and galactosylceramide by beta-galactosylceramidase (EC 220.127.116.11). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 18.104.22.168). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|
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