|Application ||WB, IHC-P, E|
|Calculated MW||19395 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB|
|Other Names||REG3A, INGAP, HIP, PAP homologous protein, PAP1, REG-III, REG3, PAP-H, Reg III-alpha, REG-3-alpha, Human proislet peptide, PBCGF|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-REG3A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HIP, PAP, PAP1|
|Function||Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.|
|Cellular Location||Secreted. Note=Found in the apical region of pancreatic acinar cells|
|Tissue Location||Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.|
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