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Anti-AQP4 / Aquaporin 4 Antibody

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P55087
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 34830 Da
Dilution IHC-P (5 µg/ml), WB (1:500 - 1:2000)
Additional Information
Gene ID 361
Alias Symbol AQP4
Other Names AQP4, Aquaporin type4, Aquaporin 4, Aquaporin-4, HMIWC2, MIWC, WCH4, AQP-4
Target/Specificity Human AQP4 / Aquaporin 4
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-AQP4 / Aquaporin 4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP4
Function Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection {ECO:0000250|UniProtKB:P47863}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries {ECO:0000250|UniProtKB:P47863}
Tissue Location Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457).
Research Areas
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Discontinued
Cat# ALS18222
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