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Anti-DMRT1 Antibody (aa1-210, clone 2H1)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y5R6
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2H1
Calculated MW 39473 Da
Dilution IHC-P (10 µg/ml), WB (1:2000)
Additional Information
Gene ID 1761
Alias Symbol DMRT1
Other Names DMRT1, DMT1
Target/Specificity Human DMRT1
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-DMRT1 Antibody (aa1-210, clone 2H1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DMRT1
Synonyms DMT1
Function Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070}
Tissue Location Testis-specific. Expressed in prostate cancer (at protein level).
Research Areas
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$ 395.00
Cat# ALS18225
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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