|Application ||IHC-P, Flo|
|Calculated MW||25038 Da|
|Dilution||Flo (1:100), IHC-P (1:100 - 1:400)|
|Other Names||CD79A, CD79a antigen, Ig-alpha, MB-1, MB-1 membrane glycoprotein, Surface IgM-associated protein, MB1|
|Reconstitution & Storage||Tissue culture supernatant|
|Precautions||Anti-CD79A / CD79 Alpha Antibody (N-Terminus, clone SP18) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.|
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