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> home > Products > Primary Antibodies > Signal Transduction > Anti-MLANA / Melan-A Antibody (clone A103)
Anti-MLANA / Melan-A Antibody (clone A103)
Mouse Anti Human Monoclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IF, Flo |
|---|---|
| Primary Accession | Q16655 |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | A103 |
| Calculated MW | 13157 Da |
| Dilution | Flo (0.5 - 1 µg/10E6 cells), IF (0.5 - 1 µg/ml), IHC-P (0.5 - 5 µg/ml), WB (0.5 - 1 µg/ml) |
| Gene ID | 2315 |
|---|---|
| Alias Symbol | MLANA |
| Other Names | MLANA, Antigen LB39-AA, Antigen SK29-AA, Melan-A, Protein Melan-A, MART-1, MART1 |
| Target/Specificity | Human MLANA / Melan-A |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-MLANA / Melan-A Antibody (clone A103) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MLANA |
|---|---|
| Synonyms | MART1 |
| Function | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation |
| Tissue Location | Expression is restricted to melanoma and melanocyte cell lines and retina |
Research Areas
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Application Protocols
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