|Application ||WB, IHC-P, IF, Flo|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||13157 Da|
|Dilution||Flo (0.5 - 1 µg/10E6 cells), IF (0.5 - 1 µg/ml), IHC-P (0.5 - 5 µg/ml), WB (0.5 - 1 µg/ml)|
|Other Names||MLANA, Antigen LB39-AA, Antigen SK29-AA, Melan-A, Protein Melan-A, MART-1, MART1|
|Target/Specificity||Human MLANA / Melan-A|
|Reconstitution & Storage||Protein G purified|
|Precautions||Anti-MLANA / Melan-A Antibody (clone A103) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation|
|Tissue Location||Expression is restricted to melanoma and melanocyte cell lines and retina|
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