|Application ||WB, IHC-P, E|
|Calculated MW||30122 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||RAET1E, BA350J20.7, LETAL, RAE-1-like transcript 4, RAET1E2, RL-4, N2DL-4, N2DL4, ULBP4, NKG2D ligand 4, NKG2DL4|
|Target/Specificity||RAET1E antibody is human and mouse reactive. At least four isoforms of RAET1E are known to exist; this antibody will detect all four.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-NKG2DL4 / ULBP4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LETAL, N2DL4, ULBP4|
|Function||Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid|
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