|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||36204 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||TNFAIP1, BACURD2, BTBD34, B61, EDP1, Protein B12, B12|
|Target/Specificity||TNFAIP1 antibody is human, mouse and rat reactive. TNFAIP1 antibody is predicted to not cross-react with other TNFAIP proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-TNFAIP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.|
|Cellular Location||Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes|
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