|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||21125 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||JAGN1, Jagunal homolog 1 (Drosophila), GL009, Protein jagunal homolog 1|
|Target/Specificity||JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist; this antibody will detect all but isoform 2.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-JAGN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed.|
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