Anti-IL11 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC, E |
---|---|
Primary Accession | P20809 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 21429 Da |
Dilution | ELISA, ICC (10 µg/ml), IHC-P (10 µg/ml), WB |
Gene ID | 3589 |
---|---|
Alias Symbol | IL11 |
Other Names | IL11, AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Oprelvekin, Interleukin 11 |
Target/Specificity | IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-IL11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IL11 (HGNC:5966) |
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Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). |
Cellular Location | Secreted |
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