Anti-INPP4B Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O15327 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 104738 Da |
Dilution | ELISA, IHC-P (10 µg/ml), WB (1 - 2 µg/ml) |
Gene ID | 8821 |
---|---|
Alias Symbol | INPP4B |
Other Names | INPP4B |
Target/Specificity | INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist; this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-INPP4B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INPP4B |
---|---|
Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). |
Tissue Location | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
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