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Anti-ACVR1B / ALK4 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P36896
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 56807 Da
Dilution IHC-P (1:100), WB (1:500 - 1:1000)
Additional Information
Gene ID 91
Alias Symbol ACVR1B
Other Names ACVR1B, ACTR-IB, ACTRIB, ALK4, Activin receptor type IB, Activin A Receptor Type IB, Activin A receptor, type IB, Activin receptor-like kinase 4, ACVRLK4, ALK-4, Activin receptor type-1B, SKR2-2, SKR2
Target/Specificity Recognizes endogenous levels of ACVR1B protein.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-ACVR1B / ALK4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ACVRLK4, ALK4
Function Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver
Research Areas
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$ 395.00
Cat# ALS18261
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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