|Application ||WB, IHC-P|
|Calculated MW||34632 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:4000)|
|Other Names||SPARC, Basement-membrane protein 40, BM-40, Cysteine-rich protein, ON, Osteonectin|
|Target/Specificity||Human Osteonectin / SPARC|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-Osteonectin / SPARC Antibody (clone 2B1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane|
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