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Anti-ISCU Antibody (aa3-148)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H1K1
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 17999 Da
Dilution ELISA (1:20000 - 1:80000), IHC-P (5 µg/ml), WB (1:500 - 1:1000)
Additional Information
Gene ID 23479
Alias Symbol ISCU
Other Names ISCU, ISU2, NifU-like protein, NIFUN, HML, NIFU, HnifU
Target/Specificity Human HML / ISCU.
Reconstitution & Storage Affinity purified
PrecautionsAnti-ISCU Antibody (aa3-148) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ISCU
Synonyms NIFUN
Function Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).
Cellular Location Isoform 1: Mitochondrion
Tissue Location Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta
Research Areas
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$ 395.00
Cat# ALS18269
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