Anti-ISCU Antibody (aa3-148)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q9H1K1 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 17999 Da |
Dilution | ELISA (1:20000 - 1:80000), IHC-P (5 µg/ml), WB (1:500 - 1:1000) |
Gene ID | 23479 |
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Alias Symbol | ISCU |
Other Names | ISCU, ISU2, NifU-like protein, NIFUN, HML, NIFU, HnifU |
Target/Specificity | Human HML / ISCU. |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-ISCU Antibody (aa3-148) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ISCU (HGNC:29882) |
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Synonyms | NIFUN |
Function | [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (PubMed:30031876, PubMed:34824239, PubMed:24971490, PubMed:29576242) (Probable). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). |
Cellular Location | [Isoform 1]: Mitochondrion |
Tissue Location | Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta. |
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