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Anti-ISCU Antibody (aa3-148)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H1K1
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 17999 Da
Dilution ELISA (1:20000 - 1:80000), IHC-P (5 µg/ml), WB (1:500 - 1:1000)
Additional Information
Gene ID 23479
Alias Symbol ISCU
Other Names ISCU, ISU2, NifU-like protein, NIFUN, HML, NIFU, HnifU
Target/Specificity Human HML / ISCU.
Reconstitution & Storage Affinity purified
PrecautionsAnti-ISCU Antibody (aa3-148) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ISCU (HGNC:29882)
Synonyms NIFUN
Function [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (PubMed:30031876, PubMed:34824239, PubMed:24971490, PubMed:29576242) (Probable). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242).
Cellular Location [Isoform 1]: Mitochondrion
Tissue Location Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta.
Research Areas
Citations (0)
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Discontinued
Cat# ALS18269
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