|Application ||WB, IHC-P, E, Flo|
|Predicted||Human, Mouse, Monkey|
|Calculated MW||84660 Da|
|Dilution||ELISA (1:10000), Flo (1:200 - 1:400), IHC-P (10 µg/ml), WB (1:500 - 1:2000)|
|Other Names||HSP90AA1, EL52, HSP86, Hsp89, HSP89A, HSPC1, Heat shock 86 kDa, Hsp90, HSP90A, HSP90N, HSPCA, HSPCAL4, HSPN, LAP2, HSP 86, HSPCAL1|
|Reconstitution & Storage||Purified|
|Precautions||Anti-HSP90AA1 / Hsp90 Alpha A1 Antibody (aa275-484, clone 5G5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSP90A, HSPC1, HSPCA|
|Function||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.|
|Cellular Location||Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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