|Application ||WB, IHC-P, E, Flo|
|Predicted||Human, Mouse, Monkey|
|Calculated MW||84660 Da|
|Dilution||ELISA (1:10000), Flo (1:200 - 1:400), IHC-P (10 µg/ml), WB (1:500 - 1:2000)|
|Other Names||HSP90AA1, EL52, HSP86, Hsp89, HSP89A, HSPC1, Heat shock 86 kDa, Hsp90, HSP90A, HSP90N, HSPCA, HSPCAL4, HSPN, LAP2, HSP 86, HSPCAL1|
|Reconstitution & Storage||Purified|
|Precautions||Anti-HSP90AA1 / Hsp90 Alpha A1 Antibody (aa275-484, clone 5G5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSP90A, HSPC1, HSPCA|
|Function||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11274138, PubMed:11276205, PubMed:15577939, PubMed:15937123, PubMed:27353360).|
|Cellular Location||Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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