|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||60329 Da|
|Dilution||IHC-P (1:50), WB (1:500 - 1:1000)|
|Other Names||THBD, BDCA3, CD141 antigen, CD141, AHUS6, Fetomodulin, THPH12, TM, THRM, Thrombomodulin|
|Target/Specificity||Recognizes endogenous levels of CD141 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-THBD / CD141 / Thrombomodulin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endothelial cells are unique in synthesizing thrombomodulin|
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