|Application ||IHC-P, IF, ICC|
|Calculated MW||263830 Da|
|Dilution||ICC (1:100 - 1:1000), IF (1:100 - 1:1000), IHC-P (5 µg/ml)|
|Other Names||SON, C21orf50, DBP5, DBP-5, KIAA1019, NREBP, Protein SON, Protein DBP-5, SON DNA binding protein, NRE-binding protein, SON3, BASS1|
|Target/Specificity||Human DBP5 / SON.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-DBP5 / SON Antibody (aa1413-1628) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf50, DBP5, KIAA1019, NREBP|
|Function||RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680).|
|Cellular Location||Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2|
|Tissue Location||Widely expressed, with the higher expression seen in leukocyte and heart|
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