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Anti-CHP2 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43745
Predicted Human, Mouse, Rat, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 22452 Da
Dilution IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000)
Additional Information
Gene ID 63928
Alias Symbol CHP2
Other Names CHP2, HCA520
Target/Specificity Recognizes endogenous levels of CHP2 protein.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-CHP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHP2
Synonyms HCA520
Function Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Cellular Location Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.
Tissue Location Expressed in malignantly transformed cells but not detected in normal tissues.
Research Areas
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$ 395.00
Cat# ALS18286
(40 western blots)
Availability: 5 days
Bulk Size
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