Anti-CHP2 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IP |
---|---|
Primary Accession | O43745 |
Predicted | Human, Mouse, Rat, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 22452 Da |
Dilution | IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000) |
Gene ID | 63928 |
---|---|
Alias Symbol | CHP2 |
Other Names | CHP2, HCA520 |
Target/Specificity | Recognizes endogenous levels of CHP2 protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-CHP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CHP2 |
---|---|
Synonyms | HCA520 |
Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
Cellular Location | Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. |
Tissue Location | Expressed in malignantly transformed cells but not detected in normal tissues. |
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