|Application ||WB, IHC-P, IP|
|Predicted||Human, Mouse, Rat, Monkey|
|Calculated MW||22452 Da|
|Dilution||IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000)|
|Other Names||CHP2, HCA520|
|Target/Specificity||Recognizes endogenous levels of CHP2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CHP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.|
|Tissue Location||Expressed in malignantly transformed cells but not detected in normal tissues.|
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