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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-NR3C1/Glucocorticoid Receptor Antibody (aa171-220)
Anti-NR3C1/Glucocorticoid Receptor Antibody (aa171-220)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P04150 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 85659 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 2908 |
|---|---|
| Alias Symbol | NR3C1 |
| Other Names | NR3C1, Glucocorticoid Receptor beta, GR, GCCR, GCR, Glucocorticoid receptor, Glucocorticoid receptor alpha, GRL |
| Target/Specificity | GR (Ab-203) Antibody detects endogenous levels of total GR protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-NR3C1/Glucocorticoid Receptor Antibody (aa171-220) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NR3C1 (HGNC:7978) |
|---|---|
| Synonyms | GRL |
| Function | Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). |
| Cellular Location | [Isoform Alpha]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628} [Isoform Alpha-B]: Nucleus. Cytoplasm Note=After ligand activation, translocates from the cytoplasm to the nucleus. |
| Tissue Location | Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803) [Isoform Alpha-2]: Widely expressed. |
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