|Application ||WB, IHC-P, E|
|Calculated MW||93926 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||KAT2A, GCN5, HsGCN5, K(lysine) acetyltransferase 2A, GCN5L2, Lysine acetyltransferase 2A, Histone acetyltransferase GCN5, HGCN5, PCAF-b, STAF97|
|Target/Specificity||GCN5L2 Antibody detects endogenous levels of total GCN5L2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-KAT2A / GCN5 Antibody (aa691-740) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GCN5, GCN5L2, HGCN5|
|Function||Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non- histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.|
|Tissue Location||Expressed in all tissues tested, with most abundant expression in ovary|
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