|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||71656 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||CDC16, ANAPC6, APC6, CDC16 homolog, Cyclosome subunit 6, CDC16Hs, CUT9|
|Target/Specificity||APC6 Antibody detects endogenous levels of total APC6 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-APC6 / CDC16 Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle|
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