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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-TSAP6 / STEAP3 Antibody
Anti-TSAP6 / STEAP3 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
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- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q658P3 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 54601 Da |
| Dilution | IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 55240 |
|---|---|
| Alias Symbol | STEAP3 |
| Other Names | STEAP3, Dudulin-2, Dudlin 2, Dudlin-2, Dudulin 2, Metalloreductase STEAP3, HTSAP6, PHyde, Tumor suppressor pHyde, TSAP6, HpHyde, STMP3 |
| Target/Specificity | Human TSAP6 / STEAP3 |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-TSAP6 / STEAP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STEAP3 |
|---|---|
| Synonyms | TSAP6 |
| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q8CI59}; Multi-pass membrane protein. Note=Localizes to vesicular- like structures at the plasma membrane and around the nucleus |
| Tissue Location | Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. |
Research Areas
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Application Protocols
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