|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||54601 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||STEAP3, Dudulin-2, Dudlin 2, Dudlin-2, Dudulin 2, Metalloreductase STEAP3, HTSAP6, PHyde, Tumor suppressor pHyde, TSAP6, HpHyde, STMP3|
|Target/Specificity||Human TSAP6 / STEAP3|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-TSAP6 / STEAP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus|
|Tissue Location||Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.|
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