|Application ||WB, IHC-P|
|Calculated MW||66932 Da|
|Dilution||IHC-P (1:100), WB (1:200 - 1:2000)|
|Other Names||NOX4, Kidney oxidase-1, KOX, RENOX, KOX-1, NADPH oxidase 4, Renal NAD(P)H-oxidase|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-NOX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus|
|Tissue Location||Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells|
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