|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||62521 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||CES1, ACAT, Brain carboxylesterase hBr1, Carboxylesterase 1, Carboxylesterase 2 (liver), CEH, CES1A1, CES1A2, Cocaine carboxylesterase, Egasyn, HMSE, Liver carboxylesterase 1, HCE-1, PCE-1, Retinyl ester hydrolase, TGH, Triacylglycerol hydrolase, REH ...|
|Target/Specificity||Human Carboxylesterase 1 / CES1|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-Carboxylesterase 1 / CES1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Expressed predominantly in liver with lower levels in heart and lung.|
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